Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0014800 Exon-Exon chr3:152163281-152165480 chr3:152445492-152447691 120 nt 0.5750
hsa_MBNL1_0015000 Exon-Exon chr3:152164493-152165562 chr3:152446704-152447773 208 nt 0.4952
hsa_chr3_0291300 Intergenic-Intergenic chr3:152164544-152165373 chr3:152446755-152447584 830 nt 0.3325
hsa_MBNL1_0015100 Exon-Exon chr3:152165409-152173366 chr3:152447620-152455577 36 nt 0.4722
hsa_MBNL1_0015200 Exon-Exon chr3:152165409-152174150 chr3:152447620-152456361 95 nt 0.5895
hsa_MBNL1_0015300 Intron-Intron chr3:152165563-152173263 chr3:152447774-152455474 250 nt 0.2800
hsa_MBNL1_0015600 Intron-Exon-Intron chr3:152173331-152175982 chr3:152455542-152458193 1963 nt 0.3571
hsa_MBNL1_0015700 Exon-Exon chr3:152174056-152177134 chr3:152456267-152459345 170 nt 0.4941
hsa_MBNL1_0015800 Exon-Exon chr3:152174056-152180223 chr3:152456267-152462434 56 nt 0.4464
hsa_MBNL1_0015900 Intron-Intron chr3:152178746-152179306 chr3:152460957-152461517 561 nt 0.3725
Showing 171 to 180 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].