Basic Information
Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1
EXP
KIAA0428
MBNL
Triplet-Expansion RNA-Binding Protein
Muscleblind-Like Protein 1
EXP42
EXP40
EXP35
Muscleblind-Like Splicing Regulator 1
Muscleblind (Drosophila)-Like
Muscleblind-Like (Drosophila)
Muscleblind-Like
Location (GRCh37)
3:151961621-152183569
UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_MBNL1_0016000 | Exon-Exon | chr3:152180456-152180609 | chr3:152462667-152462820 | 154 nt | 0.2857 |
| hsa_MBNL1_0016100 | Exon-Exon | chr3:152180828-152181091 | chr3:152463039-152463302 | 264 nt | 0.2917 |
| hsa_MBNL1_0016200 | Exon-Exon | chr3:152182333-152182590 | chr3:152464544-152464801 | 258 nt | 0.3023 |
| hsa_RP11-362A9.3_0000100 | Intron-Intron | chr3:152180196-152180475 | chr3:152462407-152462686 | 280 nt | 0.3750 |
| hsa_RP11-362A9.3_0000200 | Intron-Intron | chr3:152180616-152181985 | chr3:152462827-152464196 | 1370 nt | 0.3109 |
| hsa_TMEM14E_0000100 | Intergenic-Exon-Intergenic | chr3:152040511-152097274 | chr3:152322722-152379485 | 250 nt | 0.2360 |
Showing 181 to 186 of 186 entries
Forensic Context
A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].