Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0000400 Intergenic-Intron chr3:151961621-152018762 chr3:152243832-152300973 101 nt 0.5743
hsa_MBNL1_0000600 Intergenic-Intron chr3:151961639-152043306 chr3:152243850-152325517 203 nt 0.4631
hsa_MBNL1_0000500 Intergenic-Exon chr3:151961639-152132900 chr3:152243850-152415111 250 nt 0.4280
hsa_MBNL1_0000700 Intergenic-Exon chr3:151962110-152150709 chr3:152244321-152432920 495 nt 0.4808
hsa_MBNL1_0000800 Intergenic-Intron chr3:151984981-151993221 chr3:152267192-152275432 250 nt 0.3520
hsa_MBNL1_0001000 Exon-Intron chr3:151986734-152173366 chr3:152268945-152455577 164 nt 0.5427
hsa_MBNL1_0001100 Intron-Intron chr3:151991507-151991660 chr3:152273718-152273871 154 nt 0.3052
hsa_MBNL1_0001200 Intron-Intron chr3:151993273-152015355 chr3:152275484-152297566 250 nt 0.3960
hsa_MBNL1_0001300 Intron-Intron chr3:151994624-151996621 chr3:152276835-152278832 1998 nt 0.3103
hsa_chr3_0288600 Intergenic-Intergenic chr3:151995809-151996659 chr3:152278020-152278870 851 nt 0.3220
Showing 11 to 20 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].