Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0001400 Intron-Intron chr3:151996742-151996891 chr3:152278953-152279102 150 nt 0.4333
hsa_MBNL1_0001500 Intron-Intron chr3:152000566-152000865 chr3:152282777-152283076 300 nt 0.3800
hsa_MBNL1_0001600 Intron-Intron chr3:152000663-152000865 chr3:152282874-152283076 203 nt 0.4335
hsa_MBNL1_0001700 Intron-Intron chr3:152003691-152004505 chr3:152285902-152286716 815 nt 0.1779
hsa_MBNL1_0001800 Intron-Intron chr3:152008179-152008892 chr3:152290390-152291103 714 nt 0.3417
hsa_MBNL1_0001900 Intron-Intron chr3:152013416-152013724 chr3:152295627-152295935 309 nt 0.4369
hsa_MBNL1_0002000 Intron-Exon-Intron chr3:152016047-152018156 chr3:152298258-152300367 63 nt 0.2857
hsa_MBNL1_0002600 Intron-Exon-Intron chr3:152017194-152018762 chr3:152299405-152300973 99 nt 0.4545
hsa_MBNL1_0002300 Intron-Exon-Intron chr3:152017194-152020758 chr3:152299405-152302969 250 nt 0.4000
hsa_MBNL1_0002700 Intron-Exon-Intron chr3:152017194-152043306 chr3:152299405-152325517 139 nt 0.3813
Showing 21 to 30 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].