Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0002400 Intron-Exon-Intron chr3:152017194-152048731 chr3:152299405-152330942 250 nt 0.3720
hsa_MBNL1_0002800 Intron-Exon-Intron chr3:152017194-152053019 chr3:152299405-152335230 120 nt 0.4333
hsa_MBNL1_0002500 Intron-Exon-Intron chr3:152017194-152056462 chr3:152299405-152338673 250 nt 0.3920
hsa_MBNL1_0002900 Exon-Exon chr3:152017194-152132900 chr3:152299405-152415111 171 nt 0.4912
hsa_MBNL1_0003000 Exon-Exon chr3:152017194-152150709 chr3:152299405-152432920 375 nt 0.5120
hsa_MBNL1_0003100 Exon-Exon chr3:152017194-152164546 chr3:152299405-152446757 54 nt 0.5556
hsa_MBNL1_0003300 Exon-Intron chr3:152017249-152018762 chr3:152299460-152300973 1514 nt 0.3930
hsa_chr3_0288700 Intergenic-Intergenic chr3:152017308-152017756 chr3:152299519-152299967 449 nt 0.4187
hsa_chr3_0288800 Intergenic-Intergenic chr3:152017315-152017740 chr3:152299526-152299951 426 nt 0.4178
hsa_chr3_0288900 Intergenic-Intergenic chr3:152017315-152017756 chr3:152299526-152299967 442 nt 0.4140
Showing 31 to 40 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].