Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0003700 Exon-Intron chr3:152017994-152043306 chr3:152300205-152325517 262 nt 0.4504
hsa_MBNL1_0003800 Exon-Intron chr3:152017994-152052588 chr3:152300205-152334799 356 nt 0.3764
hsa_MBNL1_0003900 Exon-Exon chr3:152017994-152132900 chr3:152300205-152415111 163 nt 0.4540
hsa_MBNL1_0004000 Exon-Exon chr3:152017994-152163328 chr3:152300205-152445539 592 nt 0.4865
hsa_MBNL1_0004100 Exon-Exon chr3:152017994-152164546 chr3:152300205-152446757 217 nt 0.4793
hsa_MBNL1_0003400 Exon-Exon chr3:152017994-152165562 chr3:152300205-152447773 950 nt 0.4937
hsa_MBNL1_0004200 Exon-Exon chr3:152017994-152174150 chr3:152300205-152456361 429 nt 0.4988
hsa_MBNL1_0003500 Exon-Exon chr3:152017994-152175982 chr3:152300205-152458193 955 nt 0.5079
hsa_MBNL1_0003600 Exon-Exon chr3:152017994-152182912 chr3:152300205-152465123 250 nt 0.3600
hsa_MBNL1_0004400 Exon-Intron chr3:152018042-152043306 chr3:152300253-152325517 208 nt 0.4567
Showing 41 to 50 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].