Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0004300 Exon-Exon chr3:152018042-152174150 chr3:152300253-152456361 829 nt 0.4982
hsa_MBNL1_0004500 Exon-Exon chr3:152018108-152174150 chr3:152300319-152456361 220 nt 0.4727
hsa_MBNL1_0004600 Intron-Exon-Intron chr3:152018670-152165562 chr3:152300881-152447773 247 nt 0.4656
hsa_MBNL1_0004700 Intron-Intron chr3:152019166-152019389 chr3:152301377-152301600 224 nt 0.3170
hsa_MBNL1_0004800 Intron-Intron chr3:152019781-152020470 chr3:152301992-152302681 690 nt 0.2942
hsa_MBNL1_0004900 Intron-Intron chr3:152021335-152022056 chr3:152303546-152304267 722 nt 0.3116
hsa_MBNL1_0005000 Intron-Intron chr3:152021952-152022622 chr3:152304163-152304833 671 nt 0.3458
hsa_MBNL1_0005100 Intron-Intron chr3:152021987-152022496 chr3:152304198-152304707 510 nt 0.3431
hsa_chr3_0289000 Intergenic-Intergenic chr3:152025009-152025793 chr3:152307220-152308004 785 nt 0.3452
hsa_MBNL1_0005200 Intron-Intron chr3:152025264-152025654 chr3:152307475-152307865 391 nt 0.3248
Showing 51 to 60 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].