Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr3_0289100 Intergenic-Intergenic chr3:152025679-152026245 chr3:152307890-152308456 567 nt 0.3933
hsa_chr3_0289200 Intergenic-Intergenic chr3:152027084-152027273 chr3:152309295-152309484 190 nt 0.3211
hsa_MBNL1_0005300 Intron-Intron chr3:152036467-152038239 chr3:152318678-152320450 1773 nt 0.3322
hsa_MBNL1_0005500 Intron-Intron chr3:152043132-152048731 chr3:152325343-152330942 175 nt 0.3886
hsa_MBNL1_0005400 Intron-Exon-Intron chr3:152043132-152165562 chr3:152325343-152447773 250 nt 0.3520
hsa_MBNL1_0005600 Intron-Exon-Intron chr3:152043132-152173366 chr3:152325343-152455577 211 nt 0.4028
hsa_MBNL1_0005700 Intron-Intron chr3:152043168-152048731 chr3:152325379-152330942 203 nt 0.3941
hsa_MBNL1_0005800 Intron-Exon-Intron chr3:152043168-152057138 chr3:152325379-152339349 98 nt 0.2551
hsa_MBNL1_0005900 Intron-Exon-Intron chr3:152043168-152057141 chr3:152325379-152339352 259 nt 0.4054
hsa_MBNL1_0006000 Intron-Exon-Intron chr3:152043168-152132900 chr3:152325379-152415111 411 nt 0.3990
Showing 61 to 70 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].