Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0006100 Intron-Exon-Intron chr3:152043168-152150709 chr3:152325379-152432920 139 nt 0.3813
hsa_MBNL1_0006200 Intron-Exon-Intron chr3:152043168-152165562 chr3:152325379-152447773 208 nt 0.4952
hsa_MBNL1_0006300 Intron-Intron chr3:152044508-152044650 chr3:152326719-152326861 143 nt 0.2727
hsa_MBNL1_0006400 Intron-Exon-Intron chr3:152048668-152056462 chr3:152330879-152338673 64 nt 0.4219
hsa_MBNL1_0006500 Intron-Exon-Intron chr3:152048668-152165562 chr3:152330879-152447773 171 nt 0.4912
hsa_chr3_0289400 Intergenic-Intergenic chr3:152048985-152050823 chr3:152331196-152333034 1839 nt 0.3834
hsa_chr3_0289500 Intergenic-Intergenic chr3:152049562-152049787 chr3:152331773-152331998 226 nt 0.5221
hsa_MBNL1_0006600 Intron-Exon-Intron chr3:152050817-152056462 chr3:152333028-152338673 250 nt 0.3480
hsa_chr3_0289600 Intergenic-Intergenic chr3:152052108-152052660 chr3:152334319-152334871 553 nt 0.3020
hsa_MBNL1_0006800 Intron-Exon-Intron chr3:152052214-152053019 chr3:152334425-152335230 806 nt 0.3710
Showing 71 to 80 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].