Basic Information

Symbol
circMBNL1
RNA Class
circRNA
Alias
Muscleblind Like Splicing Regulator 1 EXP KIAA0428 MBNL Triplet-Expansion RNA-Binding Protein Muscleblind-Like Protein 1 EXP42 EXP40 EXP35 Muscleblind-Like Splicing Regulator 1 Muscleblind (Drosophila)-Like Muscleblind-Like (Drosophila) Muscleblind-Like
Location (GRCh37)
3:151961621-152183569 UCSC Genome Browser
Location (GRCh38)
3:152243832-152465780
UCSC Genome Browser Search in Marker Scope
Host gene
MBNL1
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_MBNL1_0006700 Intron-Exon-Intron chr3:152052214-152063233 chr3:152334425-152345444 250 nt 0.2920
hsa_MBNL1_0006900 Intron-Exon-Intron chr3:152052501-152056462 chr3:152334712-152338673 250 nt 0.2880
hsa_MBNL1_0007000 Intron-Exon-Intron chr3:152052501-152063233 chr3:152334712-152345444 250 nt 0.2520
hsa_MBNL1_0007100 Intron-Exon-Intron chr3:152052501-152165562 chr3:152334712-152447773 88 nt 0.2727
hsa_MBNL1_0007300 Intron-Exon-Intron chr3:152052900-152056462 chr3:152335111-152338673 120 nt 0.4333
hsa_MBNL1_0007400 Intron-Exon-Intron chr3:152052900-152057138 chr3:152335111-152339349 120 nt 0.4333
hsa_MBNL1_0007500 Exon-Exon chr3:152052900-152132900 chr3:152335111-152415111 171 nt 0.4912
hsa_MBNL1_0007200 Exon-Exon chr3:152052900-152150709 chr3:152335111-152432920 553 nt 0.4882
hsa_MBNL1_0007600 Intron-Exon-Intron chr3:152052900-152155235 chr3:152335111-152437446 120 nt 0.4333
hsa_MBNL1_0007700 Exon-Exon chr3:152052900-152163328 chr3:152335111-152445539 258 nt 0.5039
Showing 81 to 90 of 186 entries
Forensic Context

A study in mice and Drosophila demonstrated that the circMBNL1 regulates the production of its linear mRNA counterpart in cis through competition with canonical splicing [Patop et al. DOI:10.15252/embj.2018100836]. A separate review confirmed its role as a splicing competitor that adversely affects canonical pre-mRNA splicing [Misir et al. DOI:10.1038/s41418-022-00948-7]. Research in mammalian neural tissue indicates that the circMBNL1 is synaptically-enriched and abundant in the dendritic arbor, suggesting a role in synaptic function [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].