Basic Information
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_chr11_0012000 | Intergenic-Intergenic | chr11:102389838-102402370 | chr11:102519107-102531639 | 250 nt | 0.3320 |
| hsa_MMP7_0000100 | Exon-Exon | chr11:102398488-102401338 | chr11:102527757-102530607 | 227 nt | 0.4009 |
Forensic Context
Research in human body fluid identification has identified circMMP7, a circular RNA, as a marker for menstrual blood, where detecting circRNAs derived from the same gene as mRNA typing could improve the stability and sensitivity of detecting this specific fluid [Li et al. DOI:10.1093/fsr/owad003]. A study in human body fluid samples demonstrated that the inclusion of circular RNA (circRNA) transcripts of circMMP7 in mRNA profiling significantly improved detection sensitivity and stability for menstrual blood identification [Zhang et al. DOI:10.1007/s00414-017-1690-7]. The use of primers targeting both linear and circular forms achieved a detection limit of 0.003 ng input RNA, enhanced detection in mixed samples and samples with fluctuating linear mRNA expression, and provided stable detection in RNase R-treated and artificially degraded menstrual bloodstains where linear-targeting primers failed. A subsequent characterization confirmed circMMP7's menstrual blood-specific expression pattern and that the inclusion of its circRNAs did not impair specificity [Liu et al. DOI:10.1007/s00414-019-02027-y].