Basic Information
Symbol
circNAPEPLD
RNA Class
circRNA
Alias
N-Acyl Phosphatidylethanolamine Phospholipase D
NAPE-PLD
C7orf18
FMP30
N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase D
NAPE-Hydrolyzing Phospholipase D
Chromosome 7 Open Reading Frame 18, N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase D
EC 3.1.4.54
EC 3.1.4
Location (GRCh37)
7:102722369-102789470
UCSC Genome Browser
Location (GRCh38)
7:103081922-103149023
Host gene
NAPEPLD
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_NAPEPLD_0005100 | Intron-Intron | chr7:102785037-102785741 | chr7:103144590-103145294 | 705 nt | 0.4156 |
| hsa_chr7_0026800 | Intergenic-Intergenic | chr7:102787454-102787608 | chr7:103147007-103147161 | 155 nt | 0.3290 |
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Forensic Context
A study in humans demonstrated that circNAPEPLD is significantly decreased in the peripheral blood of Alzheimer's disease patients and may be used to distinguish them from other dementia cases [Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in mice and humans demonstrated that circNAPEPLD is expressed in spermatozoa and specifically interacts with five miRNAs involved in cell cycle control, suggesting a role as a paternal-derived sponge for miRNAs inside fertilized oocytes [Di Agostino et al. DOI:10.3389/fcell.2020.00389].