Basic Information

Symbol
circNUBPL
RNA Class
circRNA
Alias
NUBP Iron-Sulfur Cluster Assembly Factor, Mitochondrial HuInd1 C14orf127 IND1 Iron-Sulfur Protein Required For NADH Dehydrogenase Iron-Sulfur Cluster Transfer Protein NUBPL Nucleotide Binding Protein Like IND1 Homolog FLJ12660 Chromosome 14 Open Reading Frame 127 Nucleotide Binding Protein-Like Nucleotide-Binding Protein-Like MC1DN21
Location (GRCh37)
14:32172323-32173344 UCSC Genome Browser
Location (GRCh38)
14:31703117-31704138
UCSC Genome Browser Search in Marker Scope
Host gene
NUBPL
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification Mixture deconvolution
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_NUBPL_0006100 Intron-Intron chr14:32172323-32173344 chr14:31703117-31704138 1022 nt 0.4658
Forensic Context

A study in mice demonstrated that circNUBPL is highly expressed in the brain and cerebellum, where it regulates neuronal plasticity and structural changes in the synapse during development [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in humans demonstrated that the circNUBPL is a highly specific circular RNA marker for semen identification, as part of a target RNA sequencing panel designed for body fluid contributor deconvolution in forensic mixtures [Yu et al. DOI:10.1016/j.fsigen.2025.103416]. The assay, which included 135 RNA-SNPs across 42 genes, showed that the circNUBPL exhibited high specificity for semen with no reported cross-reactivity in the tested samples, contributing to the panel's successful detection of all body fluid components in artificial mixtures and its high cumulative discriminatory power.