Basic Information

Symbol
circNUP107
RNA Class
circRNA
Alias
Nucleoporin 107 Nuclear Pore Complex Protein Nup107 NUP84 Nucleoporin 107kDa 107 KDa Nucleoporin Nucleoporin Nup107 ODG6; GAMOS7 GAMOS7 NPHS11 ODG6
Location (GRCh37)
12:69090599-69094633 UCSC Genome Browser
Location (GRCh38)
12:68696819-68700853
UCSC Genome Browser Search in Marker Scope
Host gene
NUP107
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_NUP107_0003700 Exon-Exon chr12:69090599-69094633 chr12:68696819-68700853 232 nt 0.4095
Forensic Context

A study in mice demonstrated that circNUP107 is highly expressed in brain, cerebellum, pancreatic islets, heart, colon, lung, and stomach, where it regulates cell proliferation, migration, angiogenesis, and tumorigenesis [Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in mice and human RWPE-1 cells demonstrated that cadmium exposure induces prostatic fibrosis by elevating the circNUP107, which functions as a molecular sponge for miRNA-1236-3p to subsequently activate the SHH signaling pathway, leading to increased epithelial-mesenchymal transition, primary ciliogenesis, and collagen deposition [Huang et al. DOI:10.1002/Jat.4436].