Basic Information
Symbol
circNUP133
RNA Class
circRNA
Alias
Nucleoporin 133
Nuclear Pore Complex Protein Nup133
133 KDa Nucleoporin
Nucleoporin 133kDa
Nucleoporin Nup133
FLJ10814
Nucleoporin 133kD
HNUP133
GAMOS8
NPHS18
Location (GRCh37)
1:229596358-229599423
UCSC Genome Browser
Location (GRCh38)
1:229460611-229463676
Host gene
NUP133
Host category
mRNA
Forensic tag(s)
Forensic psychiatry evaluation
Cause of death analysis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_NUP133_0005000 | Exon-Exon | chr1:229596358-229599423 | chr1:229460611-229463676 | 293 nt | 0.4232 |
Forensic Context
A study in humans demonstrated that circNUP133 is significantly decreased in the peripheral blood of Alzheimer's disease patients and may serve to distinguish them from other dementia cases [Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in human neonates demonstrated that circNUP133 hsa_circ_0112327, derived from the NUP133 gene on chromosome 17, was significantly downregulated (Fold Change = -4.26) in peripheral blood from asphyxia-induced acute kidney injury cases compared to matched controls, with this differential expression validated by quantitative real-time PCR [Pan et al. DOI:10.1002/kjm2.12644].