Forensic RNA Knowledge Base

Basic Information

Symbol

circAP4E1

RNA Class

circRNA

Alias

Adaptor Related Protein Complex 4 Subunit Epsilon 1 SPG51 Adaptor Related Protein Complex 4 Epsilon 1 Subunit AP-4 Adaptor Complex Subunit Epsilon AP-4 Complex Subunit Epsilon-1 Epsilon-Adaptin AP-4-EPSILON Adaptor-Related Protein Complex 4 Subunit Epsilon-1 Adaptor-Related Protein Complex AP-4 Epsilon Epsilon Subunit Of AP-4 CPSQ4 STUT1

Location (GRCh37)

15:51204275-51207768 UCSC Genome Browser

Location (GRCh38)

15:50912078-50915571

UCSC Genome Browser Search in Marker Scope

Host gene

AP4E1

Host category

mRNA

Forensic tag(s)

Sudden cardiac death diagnosis Sudden death from respiratory system disease Other applications

External database

circbank

Transcripts

ID	Type	Location (GRCh37)	Location (GRCh38)	Length	GC content
hsa_AP4E1_0000700	Exon-Exon	chr15:51204275-51207768	chr15:50912078-50915571	219 nt	0.3699

Forensic Context

A study in mice demonstrated that the circAP4E1 is highly expressed in early-stage hepatocellular carcinoma, bladder cancers, and breast cancer, and its decreased expression in myocardial tissues and hypoxic myocardial cells is associated with improved cardiac function after acute myocardial infarction [Sema Misir et al. DOI:10.1038/s41418-022-00948-7]. A study in humans identified the circAP4E1 as a down-regulated exonic circRNA co-differentially expressed in both plasma and lung tissue from patients with sepsis-induced acute respiratory distress syndrome [Guo et al. DOI:10.1016/j.lfs.2021.119566]. A separate review noted its involvement in multiple cancer pathways, including VEGF, angiogenesis, and HIF-1 signaling in osteosarcoma [Huang et al. DOI:10.3390/cells11091381].