Basic Information
Symbol
circP4HA1
RNA Class
circRNA
Alias
Prolyl 4-Hydroxylase Subunit Alpha 1
C-P4Halpha(I)
P4HA
Procollagen-Proline, 2-Oxoglutarate 4-Dioxygenase (Proline 4-Hydroxylase), Alpha Polypeptide I
Procollagen-Proline,2-Oxoglutarate-4-Dioxygenase Subunit Alpha-1
Prolyl 4-Hydroxylase, Alpha Polypeptide I
Collagen Prolyl 4-Hydroxylase Alpha(I)
Prolyl 4-Hydroxylase Subunit Alpha-1
EC 1.14.11.2
4-PH Alpha-1
Location (GRCh37)
10:74790029-74831938
UCSC Genome Browser
Location (GRCh38)
10:73030271-73072180
Host gene
P4HA1
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_P4HA1_0005900 | Exon-Exon | chr10:74790029-74831938 | chr10:73030271-73072180 | 1075 nt | 0.4214 |
Forensic Context
A study in mice demonstrated that the circP4HA1 is highly expressed in early stages of hepatocellular carcinoma, bladder cancers, and breast cancer [Misir et al. DOI:10.1038/s41418-022-00948-7]. In human hepatocellular carcinoma, it promotes stem-like characteristics and tumor growth via the miR-328-3p/HIF1AN axis under hypoxic conditions [Huang et al. DOI:10.3390/cells11091381]. A study in human cervical cancer patients demonstrated that circP4HA1 is a differentially expressed circRNA (DE-circRNA) in cervical tumors versus matched normal tissues, and high expression of its host gene correlates with poor disease-free survival [Li et al. DOI:10.1093/bib/bby006].