Basic Information
Symbol
circPAPPA2
RNA Class
circRNA
Alias
Pappalysin 2
PAPP-A2
PAPPE
PLAC3
Pregnancy-Associated Plasma Protein E1
Placenta-Specific 3
Pappalysin-2
PAPP-E
Pregnancy-Associated Plasma Preproprotein-A2
Pregnancy-Associated Plasma Protein A2
EC 3.4.24.-
SSDA
Location (GRCh37)
1:176563660-176564731
UCSC Genome Browser
Location (GRCh38)
1:176594524-176595595
Host gene
PAPPA2
Host category
mRNA
Forensic tag(s)
Cause of death analysis
Sudden cardiac death diagnosis
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PAPPA2_0003500 | Exon-Exon | chr1:176563660-176564731 | chr1:176594524-176595595 | 1072 nt | 0.5672 |
Forensic Context
A study in mice demonstrated that the circPAPPA2 is highly expressed in early-stage hepatocellular carcinoma, bladder cancers, and breast cancer, and its decreased expression in myocardial tissues is associated with impaired cardiac function following acute myocardial infarction [Misir et al. 10.1038/s41418-022-00948-7]. Further research in human hepatocellular carcinoma showed that the circPAPPA2 promotes stem-like characteristics and tumor growth under hypoxic conditions via the miR-328-3p/HIF1AN axis [Huang et al. 10.3390/cells11091381]. A study in humans demonstrated that circPAPPA2 is upregulated in preeclampsia [Huang et al. DOI:10.3390/cells11091381].