Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0000100 Exon-Exon chr21:27252861-27264180 chr21:25880550-25891868 1369 nt 0.3930
hsa_APP_0000200 Exon-Exon chr21:27252861-27347541 chr21:25880550-25975228 2134 nt 0.4381
hsa_APP_0000800 Exon-Exon chr21:27264034-27264180 chr21:25891722-25891868 147 nt 0.4694
hsa_APP_0000900 Exon-Exon chr21:27264034-27284274 chr21:25891722-25911962 524 nt 0.4866
hsa_APP_0001000 Exon-Exon chr21:27264034-27328069 chr21:25891722-25955755 753 nt 0.4967
hsa_APP_0001800 Exon-Exon chr21:27269885-27284274 chr21:25897573-25911962 377 nt 0.4934
hsa_APP_0001900 Exon-Exon chr21:27269885-27328069 chr21:25897573-25955755 606 nt 0.5033
hsa_APP_0002500 Exon-Exon chr21:27277336-27328069 chr21:25905024-25955755 505 nt 0.5228
hsa_APP_0002800 Exon-Exon chr21:27284053-27328069 chr21:25911741-25955755 451 nt 0.5078
hsa_APP_0003900 Exon-Exon chr21:27326904-27327003 chr21:25954590-25954689 100 nt 0.5100
Showing 1 to 10 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].