Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0006000 Intron-Intron chr21:27331670-27337023 chr21:25959356-25964710 250 nt 0.3880
hsa_chr21_0026900 Intergenic-Intergenic chr21:27338934-27339196 chr21:25966621-25966883 263 nt 0.3194
hsa_APP_0006200 Intron-Intron chr21:27342707-27342905 chr21:25970394-25970592 199 nt 0.4322
hsa_APP_0006100 Intron-Exon-Intron chr21:27342707-27354790 chr21:25970394-25982477 250 nt 0.3800
hsa_APP_0006300 Intron-Intron chr21:27346361-27347258 chr21:25974048-25974945 898 nt 0.4254
hsa_APP_0007000 Intron-Exon-Intron chr21:27347383-27369756 chr21:25975070-25997441 450 nt 0.5089
hsa_APP_0007100 Intron-Exon-Intron chr21:27347383-27374847 chr21:25975070-26002532 234 nt 0.5385
hsa_APP_0007200 Exon-Exon chr21:27347383-27394358 chr21:25975070-26022042 234 nt 0.5385
hsa_APP_0007300 Intron-Exon-Intron chr21:27347383-27396836 chr21:25975070-26024520 75 nt 0.4533
hsa_APP_0007400 Exon-Exon chr21:27347383-27425664 chr21:25975070-26053348 272 nt 0.5368
Showing 91 to 100 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].