Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0007500 Exon-Exon chr21:27347383-27462388 chr21:25975070-26090072 150 nt 0.5867
hsa_APP_0007600 Exon-Exon chr21:27347383-27484463 chr21:25975070-26112146 318 nt 0.5409
hsa_APP_0006900 Intron-Exon-Intron chr21:27347383-27495299 chr21:25975070-26122982 250 nt 0.4000
hsa_APP_0007700 Exon-Exon chr21:27347527-27394312 chr21:25975214-26021996 606 nt 0.5264
hsa_APP_0007800 Exon-Exon chr21:27348267-27354790 chr21:25975954-25982477 209 nt 0.4976
hsa_APP_0007900 Exon-Exon chr21:27348267-27369731 chr21:25975954-25997416 57 nt 0.4737
hsa_APP_0008000 Exon-Exon chr21:27348267-27394208 chr21:25975954-26021892 53 nt 0.5849
hsa_chr21_0027000 Intergenic-Intergenic chr21:27348296-27354780 chr21:25975983-25982467 170 nt 0.5176
hsa_chr21_0027100 Intergenic-Intergenic chr21:27348296-27423395 chr21:25975983-26051079 688 nt 0.5334
hsa_APP_0008100 Exon-Exon chr21:27348314-27394208 chr21:25976001-26021892 81 nt 0.5556
Showing 101 to 110 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].