Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0008200 Intron-Intron chr21:27348497-27348870 chr21:25976184-25976557 374 nt 0.3235
hsa_APP_0008300 Intron-Intron chr21:27348643-27348870 chr21:25976330-25976557 228 nt 0.3289
hsa_chr21_0027200 Intergenic-Intergenic chr21:27349630-27352507 chr21:25977317-25980194 2878 nt 0.3735
hsa_APP_0008400 Exon-Exon chr21:27354657-27369702 chr21:25982344-25997387 162 nt 0.5185
hsa_APP_0008500 Exon-Exon chr21:27354657-27372497 chr21:25982344-26000182 140 nt 0.5214
hsa_APP_0008600 Exon-Exon chr21:27354657-27394358 chr21:25982344-26022042 134 nt 0.5224
hsa_chr21_0027300 Intergenic-Intergenic chr21:27354737-27394285 chr21:25982424-26021969 409 nt 0.5477
hsa_chr21_0027400 Intergenic-Intergenic chr21:27362191-27363347 chr21:25989877-25991033 1157 nt 0.3483
hsa_chr21_0027500 Intergenic-Intergenic chr21:27365542-27365747 chr21:25993228-25993433 206 nt 0.4369
hsa_APP_0008700 Intron-Intron chr21:27366741-27366958 chr21:25994426-25994643 218 nt 0.3073
Showing 111 to 120 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].