Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0008900 Exon-Exon chr21:27369675-27372497 chr21:25997360-26000182 225 nt 0.5467
hsa_APP_0009000 Intron-Exon-Intron chr21:27369675-27377971 chr21:25997360-26005656 229 nt 0.4236
hsa_APP_0009100 Exon-Exon chr21:27369675-27394358 chr21:25997360-26022042 428 nt 0.5374
hsa_chr21_0027600 Intergenic-Intergenic chr21:27369699-27394214 chr21:25997384-26021898 92 nt 0.5435
hsa_APP_0009200 Intron-Exon chr21:27372173-27372495 chr21:25999858-26000180 323 nt 0.5325
hsa_APP_0009600 Intron-Exon-Intron chr21:27372330-27374847 chr21:26000015-26002532 267 nt 0.4981
hsa_APP_0009500 Exon-Exon chr21:27372330-27394358 chr21:26000015-26022042 371 nt 0.5472
hsa_APP_0009700 Exon-Exon chr21:27372330-27484463 chr21:26000015-26112146 336 nt 0.5357
hsa_APP_0009800 Exon-Exon chr21:27372443-27394243 chr21:26000128-26021927 94 nt 0.5851
hsa_APP_0009900 Intron-Intron chr21:27382829-27387254 chr21:26010514-26014939 250 nt 0.3640
Showing 121 to 130 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].