Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0010000 Intron-Intron chr21:27383059-27383510 chr21:26010744-26011195 452 nt 0.4690
hsa_APP_0010100 Intron-Intron chr21:27386067-27386218 chr21:26013752-26013903 152 nt 0.4013
hsa_chr21_0027700 Intergenic-Intergenic chr21:27387070-27387620 chr21:26014755-26015305 551 nt 0.3067
hsa_APP_0010200 Intron-Exon-Intron chr21:27387155-27394358 chr21:26014840-26022042 250 nt 0.3480
hsa_chr21_0027800 Intergenic-Intergenic chr21:27388584-27389330 chr21:26016269-26017015 747 nt 0.4752
hsa_chr21_0027900 Intergenic-Intergenic chr21:27388810-27389298 chr21:26016495-26016983 489 nt 0.5256
hsa_APP_0010300 Intron-Intron chr21:27389118-27389318 chr21:26016803-26017003 201 nt 0.6070
hsa_APP_0010700 Intron-Exon-Intron chr21:27394156-27409762 chr21:26021840-26037447 250 nt 0.3840
hsa_APP_0010900 Exon-Exon chr21:27394156-27462388 chr21:26021840-26090072 165 nt 0.5515
hsa_APP_0010800 Intron-Exon-Intron chr21:27394156-27503543 chr21:26021840-26131226 250 nt 0.4760
Showing 131 to 140 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].