Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0011100 Exon-Exon chr21:27394175-27394312 chr21:26021859-26021996 138 nt 0.5435
hsa_APP_0011200 Exon-Exon chr21:27394262-27423368 chr21:26021946-26051052 150 nt 0.5200
hsa_APP_0011300 Exon-Exon chr21:27394313-27423371 chr21:26021997-26051055 102 nt 0.5294
hsa_APP_0011400 Exon-Exon chr21:27394313-27423436 chr21:26021997-26051120 167 nt 0.5210
hsa_chr21_0028000 Intergenic-Intergenic chr21:27394679-27395000 chr21:26022363-26022684 322 nt 0.3696
hsa_APP_0011500 Intron-Exon-Intron chr21:27421674-27425664 chr21:26049358-26053348 1949 nt 0.3930
hsa_APP_0011800 Exon-Exon chr21:27423316-27423501 chr21:26051000-26051185 186 nt 0.5323
hsa_APP_0011900 Exon-Exon chr21:27423316-27425648 chr21:26051000-26053332 291 nt 0.5189
hsa_APP_0012000 Exon-Exon chr21:27423316-27425656 chr21:26051000-26053340 299 nt 0.5117
hsa_APP_0011700 Intron-Exon-Intron chr21:27423316-27430491 chr21:26051000-26058175 250 nt 0.3960
Showing 141 to 150 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].