Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0012100 Exon-Exon chr21:27423316-27462301 chr21:26051000-26089985 350 nt 0.5143
hsa_APP_0012300 Exon-Exon chr21:27423316-27462388 chr21:26051000-26090072 194 nt 0.5309
hsa_APP_0012200 Exon-Exon chr21:27423316-27484463 chr21:26051000-26112146 605 nt 0.5174
hsa_chr21_0028100 Intergenic-Intergenic chr21:27443669-27444154 chr21:26071353-26071838 486 nt 0.3477
hsa_APP_0012900 Intron-Exon-Intron chr21:27462259-27491752 chr21:26089943-26119435 130 nt 0.5538
hsa_APP_0013000 Intron-Exon-Intron chr21:27462259-27492737 chr21:26089943-26120420 291 nt 0.4330
hsa_APP_0012800 Intron-Exon-Intron chr21:27462259-27495299 chr21:26089943-26122982 250 nt 0.3760
hsa_APP_0013100 Intron-Exon chr21:27484027-27484421 chr21:26111710-26112104 395 nt 0.3671
hsa_APP_0013300 Exon-Exon chr21:27484296-27484463 chr21:26111979-26112146 168 nt 0.5000
hsa_APP_0013200 Intron-Exon-Intron chr21:27484296-27495299 chr21:26111979-26122982 250 nt 0.3360
Showing 151 to 160 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].