Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0013400 Intron-Intron chr21:27484890-27485041 chr21:26112573-26112724 152 nt 0.3882
hsa_APP_0013600 Intron-Intron chr21:27491722-27501033 chr21:26119405-26128716 31 nt 0.3871
hsa_APP_0013500 Intron-Intron chr21:27491722-27521543 chr21:26119405-26149225 250 nt 0.3040
hsa_chr21_0028200 Intergenic-Intergenic chr21:27498585-27499322 chr21:26126268-26127005 738 nt 0.3997
hsa_APP_0013700 Intron-Intron chr21:27500009-27500298 chr21:26127692-26127981 290 nt 0.3793
hsa_APP_0013800 Intron-Intron chr21:27500207-27522770 chr21:26127890-26150452 250 nt 0.3360
hsa_APP_0013900 Intron-Intron chr21:27508416-27509334 chr21:26136098-26137016 919 nt 0.3950
hsa_chr21_0028300 Intergenic-Intergenic chr21:27520024-27521445 chr21:26147706-26149127 1422 nt 0.4304
hsa_APP_0014000 Intron-Intron chr21:27535648-27535858 chr21:26163330-26163540 211 nt 0.3744
hsa_APP_0014100 Exon-Exon chr21:27542882-27543025 chr21:26170564-26170707 144 nt 0.7569
Showing 161 to 170 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].