Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_AP001439.2_0000100 Intron-Intron chr21:27540311-27540528 chr21:26167993-26168210 218 nt 0.3119
hsa_AP001442.2_0000100 Intergenic-Exon-Intergenic chr21:27252873-27354783 chr21:25880562-25982470 250 nt 0.3400
hsa_AP001442.2_0000200 Intergenic-Exon-Intergenic chr21:27253344-27394181 chr21:25881033-26021865 250 nt 0.3440
hsa_AP001442.2_0000300 Intergenic-Exon-Intergenic chr21:27254012-27348299 chr21:25881701-25975986 33 nt 0.4242
hsa_AP001442.2_0000400 Intergenic-Exon-Intergenic chr21:27284144-27423489 chr21:25911832-26051173 305 nt 0.5049
hsa_AP001442.2_0000500 Intergenic-Exon-Intergenic chr21:27284147-27394187 chr21:25911835-26021871 32 nt 0.5625
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Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].