Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0004000 Exon-Exon chr21:27326904-27328069 chr21:25954590-25955755 229 nt 0.5197
hsa_APP_0004100 Intron-Exon-Intron chr21:27326904-27342862 chr21:25954590-25970549 250 nt 0.4040
hsa_APP_0004200 Exon-Exon chr21:27326904-27348341 chr21:25954590-25976028 463 nt 0.5292
hsa_APP_0004300 Exon-Exon chr21:27326904-27354790 chr21:25954590-25982477 597 nt 0.5276
hsa_APP_0004400 Exon-Exon chr21:27326904-27372497 chr21:25954590-26000182 822 nt 0.5328
hsa_APP_0005500 Exon-Exon chr21:27327941-27328069 chr21:25955627-25955755 129 nt 0.5271
hsa_APP_0006400 Exon-Exon chr21:27347383-27348341 chr21:25975070-25976028 234 nt 0.5385
hsa_APP_0006500 Exon-Exon chr21:27347383-27354790 chr21:25975070-25982477 368 nt 0.5326
hsa_APP_0006600 Exon-Exon chr21:27347383-27369731 chr21:25975070-25997416 425 nt 0.5247
hsa_APP_0006700 Exon-Exon chr21:27347383-27372497 chr21:25975070-26000182 593 nt 0.5379
Showing 11 to 20 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].