Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0006800 Exon-Exon chr21:27347383-27423509 chr21:25975070-26051193 990 nt 0.5343
hsa_APP_0008800 Intron-Exon-Intron chr21:27369675-27374847 chr21:25997360-26002532 2575 nt 0.4027
hsa_APP_0009300 Exon-Exon chr21:27372330-27423509 chr21:26000015-26051193 565 nt 0.5416
hsa_APP_0009400 Exon-Exon chr21:27372330-27425664 chr21:26000015-26053348 678 nt 0.5310
hsa_APP_0010400 Exon-Exon chr21:27394156-27394358 chr21:26021840-26022042 203 nt 0.5271
hsa_APP_0010500 Exon-Exon chr21:27394156-27425664 chr21:26021840-26053348 510 nt 0.5176
hsa_APP_0010600 Exon-Exon chr21:27394156-27484463 chr21:26021840-26112146 808 nt 0.5198
hsa_APP_0011000 Exon-Exon chr21:27394175-27394330 chr21:26021859-26022014 156 nt 0.5449
hsa_APP_0011600 Exon-Exon chr21:27423316-27425664 chr21:26051000-26053348 307 nt 0.5114
hsa_APP_0012400 Exon-Exon chr21:27425552-27543138 chr21:26053236-26170820 668 nt 0.6048
Showing 21 to 30 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].