Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0012500 Exon-Exon chr21:27462259-27462388 chr21:26089943-26090072 130 nt 0.5538
hsa_APP_0012600 Exon-Exon chr21:27462259-27484463 chr21:26089943-26112146 298 nt 0.5235
hsa_APP_0012700 Exon-Exon chr21:27462259-27543138 chr21:26089943-26170820 555 nt 0.6306
hsa_APP_0000300 Exon-Exon chr21:27253019-27253246 chr21:25880708-25880935 228 nt 0.3553
hsa_APP_0000400 Exon-Exon chr21:27253276-27253995 chr21:25880965-25881684 720 nt 0.3708
hsa_chr21_0025500 Intergenic-Intergenic chr21:27253332-27269972 chr21:25881021-25897660 88 nt 0.3864
hsa_chr21_0025600 Intergenic-Intergenic chr21:27253458-27254011 chr21:25881147-25881700 554 nt 0.3736
hsa_chr21_0025700 Intergenic-Intergenic chr21:27253536-27254011 chr21:25881225-25881700 476 nt 0.3908
hsa_chr21_0025800 Intergenic-Intergenic chr21:27253546-27253969 chr21:25881235-25881658 424 nt 0.3797
hsa_chr21_0025900 Intergenic-Intergenic chr21:27253551-27253949 chr21:25881240-25881638 399 nt 0.3684
Showing 31 to 40 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].