Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0000500 Exon-Exon chr21:27253739-27253986 chr21:25881428-25881675 248 nt 0.3911
hsa_chr21_0026000 Intergenic-Intergenic chr21:27253761-27254011 chr21:25881450-25881700 251 nt 0.4064
hsa_chr21_0026100 Intergenic-Intergenic chr21:27253860-27254049 chr21:25881549-25881738 44 nt 0.4773
hsa_APP_0000600 Exon-Exon chr21:27253922-27264180 chr21:25881611-25891868 308 nt 0.5097
hsa_chr21_0026200 Intergenic-Intergenic chr21:27254012-27264060 chr21:25881701-25891748 98 nt 0.5612
hsa_APP_0000700 Intron-Intron chr21:27258568-27261142 chr21:25886256-25888830 2575 nt 0.4396
hsa_APP_0001400 Exon-Exon chr21:27264034-27269985 chr21:25891722-25897673 147 nt 0.4694
hsa_APP_0001100 Exon-Exon chr21:27264034-27277353 chr21:25891722-25905041 266 nt 0.4549
hsa_APP_0001500 Exon-Exon chr21:27264034-27277389 chr21:25891722-25905077 147 nt 0.4694
hsa_APP_0001200 Exon-Exon chr21:27264034-27354790 chr21:25891722-25982477 1121 nt 0.5085
Showing 41 to 50 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].