Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0001300 Exon-Exon chr21:27264034-27372497 chr21:25891722-26000182 1346 nt 0.5149
hsa_APP_0001600 Exon-Exon chr21:27264085-27269956 chr21:25891773-25897644 78 nt 0.3974
hsa_APP_0001700 Exon-Exon chr21:27264147-27269938 chr21:25891835-25897626 88 nt 0.3864
hsa_chr21_0026300 Intergenic-Intergenic chr21:27265657-27265998 chr21:25893345-25893686 342 nt 0.4006
hsa_APP_0002000 Exon-Exon chr21:27269885-27348341 chr21:25897573-25976028 75 nt 0.4533
hsa_APP_0002100 Exon-Exon chr21:27269885-27369731 chr21:25897573-25997416 212 nt 0.4858
hsa_APP_0002200 Exon-Exon chr21:27269885-27372497 chr21:25897573-26000182 269 nt 0.5093
hsa_APP_0002300 Exon-Exon chr21:27269885-27394358 chr21:25897573-26022042 101 nt 0.4059
hsa_APP_0002400 Exon-Exon chr21:27269885-27425664 chr21:25897573-26053348 107 nt 0.4112
hsa_chr21_0026400 Intergenic-Intergenic chr21:27274050-27274942 chr21:25901738-25902630 893 nt 0.4121
Showing 51 to 60 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].