Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0002600 Exon-Exon chr21:27277336-27284274 chr21:25905024-25911962 276 nt 0.5254
hsa_APP_0002700 Exon-Exon chr21:27277336-27354790 chr21:25905024-25982477 54 nt 0.6481
hsa_APP_0002900 Exon-Exon chr21:27284053-27284274 chr21:25911741-25911962 222 nt 0.4955
hsa_APP_0003000 Exon-Exon chr21:27284053-27348322 chr21:25911741-25976009 666 nt 0.5195
hsa_APP_0003300 Exon-Exon chr21:27284053-27354790 chr21:25911741-25982477 356 nt 0.5056
hsa_APP_0003100 Exon-Exon chr21:27284053-27394358 chr21:25911741-26022042 1247 nt 0.5253
hsa_APP_0003200 Exon-Exon chr21:27284053-27462388 chr21:25911741-26090072 1684 nt 0.5249
hsa_chr21_0026500 Intergenic-Intergenic chr21:27305433-27305843 chr21:25933120-25933530 411 nt 0.4453
hsa_APP_0003400 Intron-Intron chr21:27307042-27307895 chr21:25934728-25935581 854 nt 0.4098
hsa_APP_0003500 Intron-Intron chr21:27308839-27310165 chr21:25936525-25937851 1327 nt 0.4024
Showing 61 to 70 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].