Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0003600 Intron-Intron chr21:27315760-27320057 chr21:25943445-25947742 250 nt 0.3680
hsa_APP_0003700 Intron-Intron chr21:27326052-27326240 chr21:25953738-25953926 189 nt 0.3862
hsa_APP_0003800 Intron-Exon-Intron chr21:27326900-27372497 chr21:25954586-26000182 174 nt 0.5632
hsa_APP_0004500 Intron-Exon-Intron chr21:27326904-27342865 chr21:25954590-25970552 250 nt 0.4000
hsa_APP_0004700 Exon-Exon chr21:27326904-27369731 chr21:25954590-25997416 132 nt 0.4621
hsa_APP_0004800 Intron-Exon-Intron chr21:27326904-27374847 chr21:25954590-26002532 229 nt 0.5197
hsa_APP_0004900 Exon-Exon chr21:27326904-27394358 chr21:25954590-26022042 106 nt 0.5000
hsa_APP_0005000 Intron-Exon-Intron chr21:27326904-27396836 chr21:25954590-26024520 266 nt 0.4812
hsa_APP_0004600 Exon-Exon chr21:27326904-27423509 chr21:25954590-26051193 1219 nt 0.5316
hsa_APP_0005100 Exon-Exon chr21:27326904-27425664 chr21:25954590-26053348 119 nt 0.4706
Showing 71 to 80 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].