Basic Information

Symbol
circAPP
RNA Class
circRNA
Alias
Amyloid Beta Precursor Protein Alpha-SAPP AD1 Alzheimer Disease Amyloid A4 Protein Homolog Amyloid Beta (A4) Precursor Protein Alzheimer Disease Amyloid Protein Cerebral Vascular Amyloid Peptide Amyloid-Beta Precursor Protein Amyloid Precursor Protein Peptidase Nexin-II Protease Nexin-II PN-II PreA4 ABPP APPI CVAP Amyloid-Beta (A4) Precursor Protein Beta-Amyloid Precursor Protein Testicular Tissue Protein Li 2 Beta-Amyloid Peptide(1-40) Beta-Amyloid Peptide(1-42) Amyloid Beta A4 Protein Amyloid-Beta A4 Protein Beta-Amyloid Peptide Alzheimer Disease CTFgamma ABETA AAA PN2 A4
Location (GRCh37)
21:27252861-27543138 UCSC Genome Browser
Location (GRCh38)
21:25880550-26170820
UCSC Genome Browser Search in Marker Scope
Host gene
APP
Host category
mRNA
Forensic tag(s)
Postmortem interval inference Forensic psychiatry evaluation
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_APP_0005200 Exon-Exon chr21:27326904-27462388 chr21:25954590-26090072 452 nt 0.5133
hsa_APP_0005300 Exon-Exon chr21:27326904-27484463 chr21:25954590-26112146 397 nt 0.5113
hsa_chr21_0026600 Intergenic-Intergenic chr21:27326957-27347439 chr21:25954643-25975126 104 nt 0.5769
hsa_APP_0005400 Exon-Exon chr21:27326988-27372495 chr21:25954674-26000180 129 nt 0.5271
hsa_chr21_0026700 Intergenic-Intergenic chr21:27327847-27328006 chr21:25955533-25955692 160 nt 0.5250
hsa_APP_0005600 Exon-Exon chr21:27327941-27347532 chr21:25955627-25975219 279 nt 0.5591
hsa_APP_0005700 Exon-Exon chr21:27327941-27347541 chr21:25955627-25975228 288 nt 0.5556
hsa_APP_0005800 Exon-Exon chr21:27327941-27348341 chr21:25955627-25976028 363 nt 0.5344
hsa_APP_0005900 Exon-Exon chr21:27327977-27394312 chr21:25955663-26021996 327 nt 0.5260
hsa_chr21_0026800 Intergenic-Intergenic chr21:27328004-27354674 chr21:25955690-25982361 75 nt 0.4533
Showing 81 to 90 of 176 entries
Forensic Context

A review of studies in humans, mice, and rats indicates that the circAPP demonstrates good postmortem stability in mouse cardiac tissues for up to 8 days after death and in formalin-fixed paraffin-embedded tissues, supporting its potential for postmortem interval estimation [Tian et al. DOI:10.3390/molecules26041155]. A review consolidating existing research indicates that the circAPP, a circular RNA derived from the APP gene, may translate to an Aβ-related peptide and regulate GSK-3β and tau phosphorylation, implicating it in Alzheimer's disease pathogenesis [Mehta et al. DOI:10.1016/j.pneurobio.2020.101746].