Basic Information
Symbol
circPOLE2
RNA Class
circRNA
Alias
DNA Polymerase Epsilon 2, Accessory Subunit
DPE2
DNA Polymerase Epsilon Subunit B
Polymerase (DNA Directed), Epsilon 2 (P59 Subunit)
Polymerase (DNA) Epsilon 2, Accessory Subunit
DNA Polymerase Epsilon Subunit 2
DNA Polymerase II Subunit 2
Polymerase (DNA Directed), Epsilon 2, Accessory Subunit
EC 2.7.7.7
Location (GRCh37)
14:50130033-50141145
UCSC Genome Browser
Location (GRCh38)
14:49663315-49674427
Host gene
POLE2
Host category
mRNA
Forensic tag(s)
Tissue/body fluid identification
Mixture deconvolution
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_POLE2_0004400 | Exon-Exon | chr14:50130033-50141145 | chr14:49663315-49674427 | 510 nt | 0.4039 |
Forensic Context
A study in humans demonstrated that the circPOLE2 is a venous blood-specific circRNA marker, with expression restricted to blood samples, as part of a target RNA sequencing panel for body fluid identification [Yu et al. DOI:10.1016/j.fsigen.2025.103416]. This panel, which included 135 RNA-SNPs across 42 genes, showed clear separation between body fluid types and successfully deconvoluted mixtures of 2–5 components, with the circPOLE2 contributing to a cumulative discriminatory power of 0.999993412 for venous blood.