Forensic RNA Knowledge Base

Basic Information

Symbol

circPPARA

RNA Class

circRNA

Alias

Peroxisome Proliferator Activated Receptor Alpha NR1C1 Peroxisome Proliferator-Activated Receptor Alpha HPPAR PPAR Peroxisome Proliferative Activated Receptor, Alpha Nuclear Receptor Subfamily 1 Group C Member 1 PPAR-Alpha PPARalpha

Location (GRCh37)

22:46627689-46628136 UCSC Genome Browser

Location (GRCh38)

22:46231792-46232239

UCSC Genome Browser Search in Marker Scope

Host gene

PPARA

Host category

mRNA

Forensic tag(s)

Sudden cardiac death diagnosis

External database

circbank

Transcripts

ID	Type	Location (GRCh37)	Location (GRCh38)	Length	GC content
hsa_PPARA_0007000	Exon-Exon	chr22:46627689-46628136	chr22:46231792-46232239	448 nt	0.4844

Forensic Context

A study in humans demonstrated that the circPPARA is highly expressed in the peripheral blood of patients with acute myocardial infarction (AMI) and in hypoxic human cardiomyocytes, where it is resistant to RNase R and primarily localized in the cytoplasm [Huang et al. DOI:10.1186/s40001-024-01753-3].