Basic Information
Symbol
circPREX2
RNA Class
circRNA
Alias
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2
PPP1R129
P-REX2
DEPDC2
DEP.2
Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein
Protein Phosphatase 1, Regulatory Subunit 129
PtdIns(3,4,5)-Dependent Rac Exchanger 2
DEP Domain-Containing Protein 2
FLJ12987
Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2
DEP Domain Containing 2
P-Rex2
Location (GRCh37)
8:68879396-69144158
UCSC Genome Browser
Location (GRCh38)
8:67967161-68231923
Host gene
PREX2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PREX2_0000500 | Exon-Exon | chr8:68930081-68939558 | chr8:68017846-68027323 | 402 nt | 0.3731 |
| hsa_PREX2_0000600 | Exon-Exon | chr8:68930081-68942893 | chr8:68017846-68030658 | 564 nt | 0.4078 |
| hsa_PREX2_0000700 | Exon-Exon | chr8:68930081-68956825 | chr8:68017846-68044590 | 802 nt | 0.4177 |
| hsa_PREX2_0000800 | Exon-Exon | chr8:68930081-68973014 | chr8:68017846-68060779 | 1198 nt | 0.4098 |
| hsa_PREX2_0001500 | Exon-Exon | chr8:68931784-68984805 | chr8:68019549-68072570 | 1356 nt | 0.4012 |
| hsa_PREX2_0001600 | Exon-Exon | chr8:68931784-69129953 | chr8:68019549-68217718 | 250 nt | 0.3840 |
| hsa_PREX2_0002300 | Exon-Exon | chr8:68934271-68950527 | chr8:68022036-68038292 | 503 nt | 0.4076 |
| hsa_PREX2_0002400 | Exon-Exon | chr8:68934271-68965481 | chr8:68022036-68053246 | 757 nt | 0.4148 |
| hsa_PREX2_0002500 | Exon-Exon | chr8:68934271-68973014 | chr8:68022036-68060779 | 1003 nt | 0.4138 |
| hsa_PREX2_0003400 | Exon-Exon | chr8:68939457-68973014 | chr8:68027222-68060779 | 898 nt | 0.4254 |
Showing 1 to 10 of 197 entries
Forensic Context
A study in rats demonstrated that heroin self-administration significantly regulated orbitofrontal cortex circular RNAs, with microarray analysis identifying 76 candidates; subsequent qPCR validation in biological replicates confirmed several heroin-responsive circRNAs, though the circPREX2 was identified in the initial screen but did not show significant regulation in validation assays in male or female rats after heroin [Floris et al. DOI:10.3390/ijms23031453].