Basic Information
Symbol
circPREX2
RNA Class
circRNA
Alias
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2
PPP1R129
P-REX2
DEPDC2
DEP.2
Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein
Protein Phosphatase 1, Regulatory Subunit 129
PtdIns(3,4,5)-Dependent Rac Exchanger 2
DEP Domain-Containing Protein 2
FLJ12987
Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2
DEP Domain Containing 2
P-Rex2
Location (GRCh37)
8:68879396-69144158
UCSC Genome Browser
Location (GRCh38)
8:67967161-68231923
Host gene
PREX2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PREX2_0013200 | Intron-Exon-Intron | chr8:69009252-69017447 | chr8:68097017-68105212 | 422 nt | 0.4194 |
| hsa_PREX2_0012800 | Exon-Exon | chr8:69009252-69028167 | chr8:68097017-68115932 | 958 nt | 0.4290 |
| hsa_PREX2_0013300 | Exon-Exon | chr8:69009252-69039654 | chr8:68097017-68127419 | 356 nt | 0.4466 |
| hsa_PREX2_0012900 | Exon-Exon | chr8:69009252-69050752 | chr8:68097017-68138517 | 1719 nt | 0.4421 |
| hsa_PREX2_0013000 | Exon-Exon | chr8:69009252-69058587 | chr8:68097017-68146352 | 1863 nt | 0.4369 |
| hsa_PREX2_0013400 | Exon-Exon | chr8:69009252-69069671 | chr8:68097017-68157436 | 185 nt | 0.4541 |
| hsa_PREX2_0013500 | Exon-Exon | chr8:69009252-69104760 | chr8:68097017-68192525 | 185 nt | 0.4541 |
| hsa_chr8_0416700 | Intergenic-Intergenic | chr8:69017014-69017605 | chr8:68104779-68105370 | 592 nt | 0.4375 |
| hsa_PREX2_0013600 | Exon-Exon | chr8:69020344-69028167 | chr8:68108109-68115932 | 611 nt | 0.4370 |
| hsa_PREX2_0013700 | Exon-Exon | chr8:69020344-69033284 | chr8:68108109-68121049 | 129 nt | 0.4419 |
Showing 141 to 150 of 197 entries
Forensic Context
A study in rats demonstrated that heroin self-administration significantly regulated orbitofrontal cortex circular RNAs, with microarray analysis identifying 76 candidates; subsequent qPCR validation in biological replicates confirmed several heroin-responsive circRNAs, though the circPREX2 was identified in the initial screen but did not show significant regulation in validation assays in male or female rats after heroin [Floris et al. DOI:10.3390/ijms23031453].