Basic Information
Symbol
circPREX2
RNA Class
circRNA
Alias
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2
PPP1R129
P-REX2
DEPDC2
DEP.2
Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein
Protein Phosphatase 1, Regulatory Subunit 129
PtdIns(3,4,5)-Dependent Rac Exchanger 2
DEP Domain-Containing Protein 2
FLJ12987
Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2
DEP Domain Containing 2
P-Rex2
Location (GRCh37)
8:68879396-69144158
UCSC Genome Browser
Location (GRCh38)
8:67967161-68231923
Host gene
PREX2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PREX2_0018300 | Exon-Exon | chr8:69058444-69104760 | chr8:68146209-68192525 | 517 nt | 0.4565 |
| hsa_chr8_0416900 | Intergenic-Intergenic | chr8:69064685-69065134 | chr8:68152450-68152899 | 450 nt | 0.5022 |
| hsa_PREX2_0018700 | Exon-Exon | chr8:69069557-69129953 | chr8:68157322-68217718 | 476 nt | 0.5084 |
| hsa_PREX2_0018900 | Exon-Exon | chr8:69103957-69129953 | chr8:68191722-68217718 | 361 nt | 0.5402 |
| hsa_PREX2_0019000 | Exon-Exon | chr8:69103957-69136861 | chr8:68191722-68224626 | 429 nt | 0.5385 |
| hsa_PREX2_0019100 | Intron-Intron | chr8:69107164-69107334 | chr8:68194929-68195099 | 168 nt | 0.4226 |
| hsa_chr8_0417000 | Intergenic-Intergenic | chr8:69143591-69143938 | chr8:68231356-68231703 | 348 nt | 0.3621 |
Showing 191 to 197 of 197 entries
Forensic Context
A study in rats demonstrated that heroin self-administration significantly regulated orbitofrontal cortex circular RNAs, with microarray analysis identifying 76 candidates; subsequent qPCR validation in biological replicates confirmed several heroin-responsive circRNAs, though the circPREX2 was identified in the initial screen but did not show significant regulation in validation assays in male or female rats after heroin [Floris et al. DOI:10.3390/ijms23031453].