Basic Information
Symbol
circPREX2
RNA Class
circRNA
Alias
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2
PPP1R129
P-REX2
DEPDC2
DEP.2
Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein
Protein Phosphatase 1, Regulatory Subunit 129
PtdIns(3,4,5)-Dependent Rac Exchanger 2
DEP Domain-Containing Protein 2
FLJ12987
Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2
DEP Domain Containing 2
P-Rex2
Location (GRCh37)
8:68879396-69144158
UCSC Genome Browser
Location (GRCh38)
8:67967161-68231923
Host gene
PREX2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PREX2_0018600 | Exon-Exon | chr8:69069557-69136861 | chr8:68157322-68224626 | 544 nt | 0.5110 |
| hsa_PREX2_0018800 | Exon-Exon | chr8:69103957-69104760 | chr8:68191722-68192525 | 258 nt | 0.5233 |
| hsa_PREX2_0000100 | Intron-Intron | chr8:68879396-68879822 | chr8:67967161-67967587 | 427 nt | 0.3724 |
| hsa_PREX2_0000200 | Intron-Exon-Intron | chr8:68889454-68934375 | chr8:67977219-68022140 | 105 nt | 0.3143 |
| hsa_PREX2_0000300 | Intron-Intron | chr8:68889845-68892225 | chr8:67977610-67979990 | 2381 nt | 0.3742 |
| hsa_PREX2_0000400 | Intron-Exon-Intron | chr8:68893002-68934375 | chr8:67980767-68022140 | 250 nt | 0.3160 |
| hsa_chr8_0416500 | Intergenic-Intergenic | chr8:68926376-68926980 | chr8:68014141-68014745 | 605 nt | 0.4000 |
| hsa_PREX2_0000900 | Exon-Exon | chr8:68930081-68934375 | chr8:68017846-68022140 | 300 nt | 0.3633 |
| hsa_PREX2_0001000 | Exon-Exon | chr8:68930081-68950527 | chr8:68017846-68038292 | 140 nt | 0.3857 |
| hsa_PREX2_0001100 | Exon-Exon | chr8:68930081-68965481 | chr8:68017846-68053246 | 156 nt | 0.3718 |
Showing 31 to 40 of 197 entries
Forensic Context
A study in rats demonstrated that heroin self-administration significantly regulated orbitofrontal cortex circular RNAs, with microarray analysis identifying 76 candidates; subsequent qPCR validation in biological replicates confirmed several heroin-responsive circRNAs, though the circPREX2 was identified in the initial screen but did not show significant regulation in validation assays in male or female rats after heroin [Floris et al. DOI:10.3390/ijms23031453].