Basic Information
Symbol
circPREX2
RNA Class
circRNA
Alias
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2
PPP1R129
P-REX2
DEPDC2
DEP.2
Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein
Protein Phosphatase 1, Regulatory Subunit 129
PtdIns(3,4,5)-Dependent Rac Exchanger 2
DEP Domain-Containing Protein 2
FLJ12987
Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2
DEP Domain Containing 2
P-Rex2
Location (GRCh37)
8:68879396-69144158
UCSC Genome Browser
Location (GRCh38)
8:67967161-68231923
Host gene
PREX2
Host category
mRNA
Forensic tag(s)
Drug abuse diagnoses
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PREX2_0003600 | Intron-Exon-Intron | chr8:68939457-68973434 | chr8:68027222-68061199 | 1318 nt | 0.4173 |
| hsa_PREX2_0004000 | Exon-Exon | chr8:68939457-68982119 | chr8:68027222-68069884 | 256 nt | 0.3633 |
| hsa_PREX2_0003700 | Exon-Exon | chr8:68939457-68995623 | chr8:68027222-68083388 | 1586 nt | 0.4010 |
| hsa_PREX2_0004200 | Exon-Exon | chr8:68942732-68942893 | chr8:68030497-68030658 | 162 nt | 0.4938 |
| hsa_PREX2_0004300 | Exon-Exon | chr8:68942732-68956825 | chr8:68030497-68044590 | 400 nt | 0.4625 |
| hsa_PREX2_0004400 | Exon-Exon | chr8:68942732-68968209 | chr8:68030497-68055974 | 307 nt | 0.4430 |
| hsa_PREX2_0004500 | Intron-Exon-Intron | chr8:68948875-68973014 | chr8:68036640-68060779 | 2153 nt | 0.3846 |
| hsa_PREX2_0004600 | Intron-Exon-Intron | chr8:68949948-68973014 | chr8:68037713-68060779 | 107 nt | 0.4673 |
| hsa_PREX2_0004900 | Exon-Exon | chr8:68950394-68956825 | chr8:68038159-68044590 | 104 nt | 0.5192 |
| hsa_PREX2_0005000 | Exon-Exon | chr8:68950394-68968209 | chr8:68038159-68055974 | 140 nt | 0.3857 |
Showing 61 to 70 of 197 entries
Forensic Context
A study in rats demonstrated that heroin self-administration significantly regulated orbitofrontal cortex circular RNAs, with microarray analysis identifying 76 candidates; subsequent qPCR validation in biological replicates confirmed several heroin-responsive circRNAs, though the circPREX2 was identified in the initial screen but did not show significant regulation in validation assays in male or female rats after heroin [Floris et al. DOI:10.3390/ijms23031453].