Basic Information
Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota
DXS1179E
PKCI
Atypical Protein Kinase C-Lambda/Iota
Protein Kinase C Iota Type
PRKC-Lambda/Iota
APKC-Lambda/Iota
EC 2.7.11.13
NPKC-Iota
Protein Kinase C, Iota
EC 2.7.11
Location (GRCh37)
3:169953018-170046704
UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
Transcripts
| ID | Type | Location (GRCh37) | Location (GRCh38) | Length | GC content |
|---|---|---|---|---|---|
| hsa_PRKCI_0010300 | Exon-Exon | chr3:170013699-170015181 | chr3:170295911-170297393 | 170 nt | 0.4000 |
| hsa_PRKCI_0000100 | Exon-Exon | chr3:169953018-170002384 | chr3:170235230-170284596 | 1102 nt | 0.4238 |
| hsa_PRKCI_0000200 | Exon-Exon | chr3:169953018-170009729 | chr3:170235230-170291941 | 1190 nt | 0.4227 |
| hsa_PRKCI_0002800 | Exon-Exon | chr3:169977757-169998191 | chr3:170259969-170280403 | 659 nt | 0.4401 |
| hsa_PRKCI_0002900 | Exon-Exon | chr3:169977757-170002384 | chr3:170259969-170284596 | 980 nt | 0.4245 |
| hsa_PRKCI_0004000 | Exon-Exon | chr3:169981167-169988349 | chr3:170263379-170270561 | 278 nt | 0.4964 |
| hsa_PRKCI_0004600 | Exon-Exon | chr3:169985703-169998191 | chr3:170267915-170280403 | 518 nt | 0.4402 |
| hsa_PRKCI_0006200 | Exon-Exon | chr3:169991074-169991128 | chr3:170273286-170273340 | 55 nt | 0.5091 |
| hsa_PRKCI_0006300 | Exon-Exon | chr3:169991074-170011296 | chr3:170273286-170293508 | 826 nt | 0.4092 |
| hsa_PRKCI_0006400 | Exon-Exon | chr3:169991074-170015181 | chr3:170273286-170297393 | 996 nt | 0.4076 |
Showing 1 to 10 of 114 entries
Forensic Context
A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].