Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0007100 Exon-Exon chr3:169998015-170016898 chr3:170280227-170299110 998 nt 0.4068
hsa_PRKCI_0007600 Exon-Exon chr3:169998954-169999756 chr3:170281166-170281968 185 nt 0.4108
hsa_PRKCI_0007700 Exon-Exon chr3:169998954-170002384 chr3:170281166-170284596 321 nt 0.3925
hsa_PRKCI_0007800 Intron-Exon-Intron chr3:169998954-170003674 chr3:170281166-170285886 1611 nt 0.3811
hsa_PRKCI_0007900 Exon-Exon chr3:169998954-170011296 chr3:170281166-170293508 126 nt 0.4762
hsa_PRKCI_0008100 Intron-Exon-Intron chr3:170000393-170003807 chr3:170282605-170286019 250 nt 0.3840
hsa_PRKCI_0008400 Intron-Exon-Intron chr3:170002249-170003674 chr3:170284461-170285886 253 nt 0.4545
hsa_PRKCI_0008500 Exon-Exon chr3:170002249-170011296 chr3:170284461-170293508 132 nt 0.4545
hsa_PRKCI_0008600 Exon-Exon chr3:170002249-170015181 chr3:170284461-170297393 142 nt 0.3662
hsa_PRKCI_0008300 Exon-Exon chr3:170002249-170020865 chr3:170284461-170303077 674 nt 0.4095
Showing 91 to 100 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].