Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_chr3_0356400 Intergenic-Intergenic chr3:170003615-170005620 chr3:170285827-170287832 2006 nt 0.3993
hsa_PRKCI_0008700 Intron-Exon-Intron chr3:170006134-170015181 chr3:170288346-170297393 250 nt 0.3320
hsa_PRKCI_0008800 Intron-Exon-Intron chr3:170008631-170011296 chr3:170290843-170293508 1225 nt 0.4180
hsa_PRKCI_0008900 Intron-Intron chr3:170008695-170008999 chr3:170290907-170291211 305 nt 0.4426
hsa_PRKCI_0009000 Intron-Intron chr3:170009000-170009569 chr3:170291212-170291781 570 nt 0.4018
hsa_PRKCI_0009300 Exon-Exon chr3:170009642-170011296 chr3:170291854-170293508 126 nt 0.4762
hsa_PRKCI_0009400 Exon-Exon chr3:170009642-170015181 chr3:170291854-170297393 178 nt 0.4326
hsa_PRKCI_0009500 Exon-Exon chr3:170009646-170015181 chr3:170291858-170297393 380 nt 0.4263
hsa_PRKCI_0010000 Exon-Exon chr3:170011171-170013778 chr3:170293383-170295990 206 nt 0.4223
hsa_PRKCI_0009900 Exon-Intergenic chr3:170011171-170046704 chr3:170293383-170328916 250 nt 0.3880
Showing 101 to 110 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].