Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0006500 Exon-Exon chr3:169991074-170016898 chr3:170273286-170299110 1112 nt 0.4083
hsa_PRKCI_0007500 Exon-Intergenic chr3:169998954-170023770 chr3:170281166-170305982 250 nt 0.2720
hsa_PRKCI_0008000 Exon-Exon chr3:169999670-170015181 chr3:170281882-170297393 607 nt 0.4053
hsa_PRKCI_0008200 Exon-Exon chr3:170002249-170016898 chr3:170284461-170299110 636 nt 0.4119
hsa_PRKCI_0009100 Exon-Exon chr3:170009642-170009729 chr3:170291854-170291941 88 nt 0.4091
hsa_PRKCI_0009200 Exon-Exon chr3:170009642-170016898 chr3:170291854-170299110 500 nt 0.4240
hsa_PRKCI_0009600 Exon-Exon chr3:170011171-170015181 chr3:170293383-170297393 296 nt 0.4324
hsa_PRKCI_0009700 Exon-Exon chr3:170011171-170016898 chr3:170293383-170299110 412 nt 0.4272
hsa_PRKCI_0009800 Exon-Intergenic chr3:170011171-170023770 chr3:170293383-170305982 250 nt 0.2920
hsa_PRKCI_0010200 Exon-Exon chr3:170013699-170013778 chr3:170295911-170295990 80 nt 0.3375
Showing 11 to 20 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].