Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0010300 Exon-Exon chr3:170013699-170015181 chr3:170295911-170297393 170 nt 0.4000
hsa_PRKCI_0010400 Exon-Exon chr3:170013699-170016898 chr3:170295911-170299110 286 nt 0.4056
hsa_PRKCI_0010500 Exon-Intergenic chr3:170013699-170023770 chr3:170295911-170305982 250 nt 0.2480
hsa_PRKCI_0010600 Exon-Intergenic chr3:170015092-170023770 chr3:170297304-170305982 250 nt 0.2760
hsa_PRKCI_0000300 Intron-Exon-Intron chr3:169953018-169960790 chr3:170235230-170243002 250 nt 0.3920
hsa_PRKCI_0000400 Intron-Exon-Intron chr3:169953018-169976714 chr3:170235230-170258926 250 nt 0.3000
hsa_PRKCI_0000500 Exon-Exon chr3:169953018-169981217 chr3:170235230-170263429 263 nt 0.4297
hsa_PRKCI_0001000 Exon-Exon chr3:169953018-169985788 chr3:170235230-170268000 122 nt 0.4180
hsa_PRKCI_0000600 Exon-Exon chr3:169953018-169988349 chr3:170235230-170270561 490 nt 0.4592
hsa_PRKCI_0000700 Exon-Exon chr3:169953018-169998191 chr3:170235230-170280403 781 nt 0.4366
Showing 21 to 30 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].