Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0000800 Exon-Exon chr3:169953018-169999756 chr3:170235230-170281968 966 nt 0.4317
hsa_PRKCI_0000900 Exon-Exon chr3:169953018-170016898 chr3:170235230-170299110 1602 nt 0.4238
hsa_PRKCI_0001100 Intron-Intron chr3:169959689-169960694 chr3:170241901-170242906 1006 nt 0.4324
hsa_PRKCI_0001200 Intron-Intron chr3:169960128-169960694 chr3:170242340-170242906 567 nt 0.4074
hsa_chr3_0356100 Intergenic-Intergenic chr3:169960188-169960486 chr3:170242400-170242698 299 nt 0.2709
hsa_PRKCI_0001300 Intron-Exon-Intron chr3:169960480-169981217 chr3:170242692-170263429 250 nt 0.4160
hsa_chr3_0356200 Intergenic-Intergenic chr3:169964639-169965929 chr3:170246851-170248141 1291 nt 0.4438
hsa_chr3_0356300 Intergenic-Intergenic chr3:169964992-169967270 chr3:170247204-170249482 2279 nt 0.4177
hsa_PRKCI_0001400 Intron-Exon-Intron chr3:169969055-169991128 chr3:170251267-170273340 250 nt 0.3000
hsa_PRKCI_0001500 Intron-Intron chr3:169971349-169973083 chr3:170253561-170255295 1735 nt 0.4167
Showing 31 to 40 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].