Basic Information

Symbol
circPRKCI
RNA Class
circRNA
Alias
Protein Kinase C Iota DXS1179E PKCI Atypical Protein Kinase C-Lambda/Iota Protein Kinase C Iota Type PRKC-Lambda/Iota APKC-Lambda/Iota EC 2.7.11.13 NPKC-Iota Protein Kinase C, Iota EC 2.7.11
Location (GRCh37)
3:169953018-170046704 UCSC Genome Browser
Location (GRCh38)
3:170235230-170328916
UCSC Genome Browser Search in Marker Scope
Host gene
PRKCI
Host category
mRNA
Forensic tag(s)
Other applications
External database
circbank

Transcripts

ID Type Location (GRCh37) Location (GRCh38) Length GC content
hsa_PRKCI_0001600 Intron-Intron chr3:169975548-169976714 chr3:170257760-170258926 1167 nt 0.4670
hsa_PRKCI_0002400 Intron-Exon-Intron chr3:169976543-169981217 chr3:170258755-170263429 172 nt 0.3663
hsa_PRKCI_0002100 Intron-Exon-Intron chr3:169976543-169988349 chr3:170258755-170270561 1582 nt 0.4311
hsa_PRKCI_0002200 Intron-Exon-Intron chr3:169976543-169991128 chr3:170258755-170273340 1637 nt 0.4337
hsa_PRKCI_0002300 Intron-Exon-Intron chr3:169976543-169993075 chr3:170258755-170275287 1696 nt 0.4304
hsa_PRKCI_0001700 Intron-Exon-Intron chr3:169976543-169999756 chr3:170258755-170281968 2058 nt 0.4247
hsa_PRKCI_0001800 Intron-Exon-Intron chr3:169976543-170002384 chr3:170258755-170284596 2194 nt 0.4211
hsa_PRKCI_0002500 Intron-Exon-Intron chr3:169976543-170003674 chr3:170258755-170285886 117 nt 0.5556
hsa_PRKCI_0001900 Intron-Exon-Intron chr3:169976543-170011296 chr3:170258755-170293508 2408 nt 0.4236
hsa_PRKCI_0002000 Intron-Exon-Intron chr3:169976543-170016898 chr3:170258755-170299110 2694 nt 0.4217
Showing 41 to 50 of 114 entries
Forensic Context

A study in humans demonstrated that circPRKCI is significantly upregulated in lung adenocarcinoma and squamous cell carcinoma tissues, where it promotes cancer cell proliferation, migration, and invasion by acting as a sponge for miR-545 and miR-589 to elevate E2F7 expression [Zhang et al. DOI:10.1038/s41418-022-00948-7]. A review of human studies indicates that the circPRKCI is upregulated in oesophageal squamous cell carcinoma tissues and its expression is associated with tumor differentiation and stage, while its downregulation suppresses cancer cell proliferation and migration [Lee et al. DOI:10.1016/j.biopha.2018.12.052].